Livedoid vasculitis
Livedoid vasculitis mangrupikeun panyakit kulit kronis anu sering ditingali dina awéwé ngora dugi ka pertengahan umur. Salah sahiji akronim anu digunakeun pikeun ngajelaskeun ciri-cirina nyaéta "Maag purpuric nyeri kalayan pola reticular tina ekstremitas handap" (UNGGU). Ieu pakait sareng sababaraha kasakit, kaasup hipertensi venous kronis sarta varicosities.
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References
Livedoid vasculopathy mangrupakeun kaayaan kulit langka dicirikeun ku borok nyeri nu terus datang deui dina suku handap.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy mangrupakeun kaayaan kulit langka nu ngabalukarkeun borok kambuh dina suku handap, ninggalkeun balik scars bulak katelah atrophie blanche. Sanaos panyabab pastina masih teu jelas, éta dipercaya yén paningkatan pembekuan getih (hypercoagulability) mangrupikeun faktor utama, kalayan peradangan maénkeun peran sekundér. Faktor anu nyumbang kana pembekuan kalebet kieu - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Dina biopsies, kaayaan nunjukkeun gumpalan getih di jero pembuluh, penebalan dinding pembuluh, sareng parut. Perlakuan ngalibatkeun pendekatan multi-pronged fokus kana nyegah gumpalan getih kalayan pangobatan kawas ubar anti trombosit, thinners getih, sarta terapi fibrinolytic. Rupa-rupa ubar tiasa dianggo pikeun kaayaan kulit ieu - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy mangrupakeun kaayaan langka dimana lesions lumangsung dina duanana suku. Kabentukna gumpalan getih dina pembuluh getih leutik diduga disababkeun ku ngaronjat clotting sarta ngurangan ngarecahna clot, babarengan jeung karuksakan kana lapisan kapal. Éta langkung umum di awéwé, khususna antara umur 15 sareng 50. Ngaleungitkeun ngaroko, ngurus tatu, sareng nganggo pangobatan sapertos pengencer getih sareng obat antiplatelet parantos mujarab.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
